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But it does mean the relationship between tirzepatide and headaches is more complicated than "drug causes headache." Why headaches on tirzepatide are not usually migraines There is a critical distinction that gets lost in online discussions

Activated microglia, the immune cells of the brain, release inflammatory mediators that sensitize pain pathways

it was argued that these astrocytes increase synaptogenesis through elevated secretion of synaptogenic factors and premature formation of perineuronal net